RocSite Caliper · pricing

Validate drug-safety claims with regulator-grade rigor

Adversarial pharmacovigilance on public adverse-event data. Pre-registered inputs, disproportionality analysis with PRR and Yates χ2, signed Ed25519 ledger, browser-verifiable. Start free, scale when your team converts.

Watch the system run

75 seconds, real data, real signature.

A live submission flows through pre-registration, FAERS retrieval, disproportionality analysis, signed publication, and browser-verifiable Ed25519 attestation. Watch before picking a tier.

Free 30-day trial available — pick a tier below to begin.

Free 30-day Trial

Validate real claims of your own before committing.
$0/ 30 days
No credit card required
  • 25 claim validations over 30 days
  • 5 single-drug discover scans over 30 days
  • Up to 5 team members
  • Signed Ed25519 verdicts + audit packets
  • Browser-verifiable signature page
  • Drug-class scans (Academic+)
  • API access (Pro+)
Start Free Trial

Academic

For PIs, residents, fellows, and academic medical center research groups.
Scoped to your team
Annual engagement · talk to Adam
  • 100 claims/day, 1,000/month
  • 10 drug scans/day
  • 2 drug-class scans/month
  • Up to 5 team members
  • Signed Ed25519 verdicts + audit packets
  • Per-finding pre-reg sha1 + ledger entry
  • API access (Pro+)
  • Methodology consulting (Pro+)
  • Email support · founder-direct
Scope an engagement

Professional

For pharma R&D, biotech research divisions, and CROs.
Scoped to your org
Annual engagement · talk to Adam
  • Unlimited claim validations
  • Unlimited single-drug scans
  • 20 drug-class scans/month
  • Up to 25 team members
  • Signed verdicts + audit packets + SLA
  • Custom drug-class definitions
  • API access (programmatic submit + status)
  • 4 hrs/qtr methodology consulting
  • Priority Slack support · 4-hour response
Scope an engagement

Enterprise

Self-hosted deployment for pharmacovigilance teams, regulatory-affairs groups, and compliance-bound orgs.
Contact us
Onsite deployment · scoped per institution
  • Self-hosted on your infrastructure
  • Air-gapped option
  • Unlimited everything
  • Your own Ed25519 signing keys + ledger chain
  • Custom data-source adapters (PMC, ClinicalTrials.gov, your post-market DB)
  • Internal-only ledger or shared public chain
  • Co-authored methodology papers
  • Regulatory-submission support
  • 24/7 named engineer + SLA
Contact for Enterprise
How engagements are scoped: Every paid tier is priced to the institution — run volume, team size, dataset-integration needs, and deployment model all factor in. Start with the free 30-day trial to evaluate the framework on your own hypotheses; when you're ready to scale, talk to Adam and we'll scope an Academic, Professional, or Enterprise engagement to fit.

Common questions

What's the difference between a claim validation and a discover scan?
A claim validation takes one specific drug + adverse-event pair you submit, locks the pre-registration hash, and runs the disproportionality pipeline. A discover scan takes just a drug name — the engine enumerates the top 20 adverse events on its own, validates each, and ranks the survivors. Scans are how you find what you didn't know to look for. A drug-class scan fans the same logic across every member drug of a class (SGLT2 inhibitors, GLP-1 agonists, anti-amyloid mAbs, etc.).
What's the difference between trial and Academic?
Trial gives you 25 claim validations + 5 discover scans over 30 days to evaluate. Academic gives you 100 claims/day + 10 scans/day on a paid plan, plus access to drug-class scans (2/month) and audit-trail storage. Trial is for evaluation; Academic is for actual research programs.
Can my whole team share one Academic license?
Yes — up to 5 users on Academic, 25 on Professional, unlimited on Enterprise. Each user gets their own API token, audit-logged separately.
Is there a money-back guarantee?
Annual subscriptions are non-refundable but pro-rated downgrades to monthly are available within the first 60 days if Academic isn't a fit. Email [email protected].
What happens if I run out of validations on Academic?
You hit the cap, queries are queued for the next day's reset, and you get a notification. If you consistently exceed the cap, we'll proactively offer Professional at a pro-rated upgrade.
What data does Caliper use? Can I bring my own?
Caliper v0 runs on public openFDA adverse-event reports — no credentialed data, no PHI, no DUA-restricted sources. Bringing your own dataset is an Enterprise feature only: self-hosted deployments can ingest your post-market surveillance database, internal pharmacovigilance records, or PMC/ClinicalTrials.gov-linked extracts behind your own firewall.
How does the cryptographic verification work?
Every published finding has a sha1 identifier. Open https://api.rocsitediscovery.com/caliper/verify/<sha1> in any browser — no auth — and you'll see the evidence hash, the prior-entry chain link, the Ed25519 signature, and a one-liner Python snippet to replicate the signature check against the public key. Every finding also downloads as a signed tar.gz audit packet (manifest + bundle + fragment + verify.txt) at /caliper/audit/<sha1>. Public key fingerprints are at /keys/; pin them for offline verification.
What does Enterprise include?
Self-hosted deployment, your own Ed25519 signing keys, internal-only ledger chain (or shared with the public chain), custom data-source adapters for your post-market DB or PMC/ClinicalTrials.gov, regulatory-submission support, dedicated engineer, white-glove onboarding, 24/7 SLA, and co-authored methodology validation. Contact Adam to scope it.
Can I switch tiers mid-year?
Yes — engagements can move up or down at renewal, and an Academic → Professional upgrade can be pro-rated mid-term. Talk to Adam and we'll work it out.
Do you offer academic or grant-funded pricing?
Academic engagements are scoped with research-budget realities in mind, and NIH/NSF-funded labs can apply for the academic-grant tier (case-by-case review). Multi-year commitments are also accommodated — talk to Adam.